Interleukin-36/IL-36/IL-1F9 | E21-M77

Interleukin-36/IL-36/IL-1F9 | E21-M77 | Gentaur UK, US & Europe Distribution

Short Description: Recombinant Human Interleukin-36 gamma is produced by our E.coli expression system and the target gene encoding Ser18-Asp169 is expressed.

Shipping: Ambient

Formulation: Lyophilized from a 0.2 m filtered solution of 20mM Tris, 100mM Nacl, 0.1mM EDTA, pH8.0.

Storage: Lyophilized protein should be stored at < -20C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20C for 3 months.

Reconstitution: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 g /ml.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Purity: Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin: Less than 0.1 ng/g (1 IEU/g) as determined by LAL test.

Background: Interleukin-36 gamma (IL-36) is a member of the interleukin 1 cytokine family that includes three closely related genes, IL-36, , and , formerly known as IL-1F6, F8, and F9 respectively. IL-36 has been detected in both neuronal and synovial tissue, whereas IL-36 and IL-36 are expressed in both cutaneous and mucosal epithelial cells, including the respiratory tract. IL-36 and IL-36 stimulate proliferation, maturation and/or cytokine expression by innate immune cells (such as keratinocytes and dendritic cells) , and adaptive immune cells (neutrophils and T-cells) in both humans and mice. The activity of IL-36 is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2) , and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta) . IL-36 plays an important role in communicating the cell death to surrounding cells.

Species: Human

Expression System: E.coli