INTS4 polyclonal Antibody | BS8145

INTS4 polyclonal Antibody | BS8145 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB 1:500 - 1:2000

Background: RNA polymerase II (Pol II) is an enzyme that is composed of twelve subunits and is responsible for the transcription of protein-coding genes. Transcription initiation requires Pol II-mediated recruitment of transcription machinery to a target promoter, thereby allowing transcription to begin. The integrator complex is a multi-protein complex that associates with the C-terminal domain of Pol II and is involved in small nuclear RNA (snRNA) transcription and 3’-end processing. INTS4 (Integrator complex subunit 4) is a 963 amino acid protein that contains eight HEAT repeats and is a component of the integrator complex. Localized to the nucleus, INTS4 plays a role in the processing of select snRNAs and mediates snRNA transcriptional regulation events. Four isoforms of INTS4 are expressed due to alternative splicing events.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: INTS4 polyclonal Antibody detects endogenous levels of INTS4 protein.

Molecular Weight: ~ 108 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Integrator complex subunit 4; Int4; INTS4; MSTP093

Immunogen: Recombinant full length Human INTS4.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: