IRAK-2 (V235) polyclonal Antibody | BS9188

IRAK-2 (V235) polyclonal Antibody | BS9188 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: The interleukin-1 receptor-associated kinases (IRAKs) are important downstream signaling components of Toll-like receptors (TLRs) . Four mammalian IRAKs have been found, namely IRAK-1, IRAK-2, IRAK-4, and IRAK-M, all of which share sequence homology to the Drosophila melanogaster protein kinase Pelle, and all contain a death domain (DD) . The DD is used for protein-protein interactions with the DDs of other molecules, IRAK2 uses its DD to mediate its interaction with MyD88. The IRAKs have putative kinase domains, although IRAK1 has dispensable kinase activity because interleukin-1-induced NF-B activation could still be driven by a kinase-inactive mutant.Due to the absence of certain key residues within their putative kinase domains, both IRAK2 and IRAK-M are catalytically inactive.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IRAK-2 (V235) polyclonal Antibody detects endogenous levels of IRAK-2 protein.

Molecular Weight: ~ 62 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Interleukin-1 receptor-associated kinase-like 2; IRAK2

Immunogen: Synthetic peptide, corresponding to amino acids 211-260 of Human IRAK-2.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: