BW
IRF-3 (V391) polyclonal Antibody | BS3244
- SKU:
- BW-BS3244
- Availability:
- Usually ships in 5 working days
Description
IRF-3 (V391) polyclonal Antibody | BS3244 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: IHC
Application Range: IHC:1:50~1:200
Background: IRF-3 can inhibit cell growth and plays a critical role in controlling the expression of genes in the innate immune response. In unstimulated cells, IRF-3 is present in the cytoplasm. Viral infection results in phosphorylation of IRF-3 and leads to its translocation to the nucleus where it activates promoters containing IRF-3-binding sites. Phosphorylation of IRF-3 occurs at a cluster of C-terminal Ser and Thr residues (between 385 and 405), leading to its association with the p300/CBP coactivator protein that promotes DNA binding and transcriptional activity. During infection, IRF-3 is likely activated through a pathway that includes activation of Toll-like receptors and a kinase complex that includes IKKε and TBK1. IRF-3 is phosphorylated at Ser396 following viral infection, expression of viral nucleocapsid, and double-stranded RNA treatment. These events likely play a role in activation of IRF-3.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: IRF-3 (V391) polyclonal Antibody detects endogenous levels of IRF-3 protein.
Molecular Weight: ~ 47, 55 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: IRF3; IRF-3; IRF3; Interferon regulatory factor 3
Immunogen: Synthetic peptide, corresponding to amino acids 358-412 of Human IRF-3.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: