IRF3 (Phospho-S386) polyclonal Antibody | BS94024

IRF3 (Phospho-S386) polyclonal Antibody | BS94024 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB ICC/IF

Application Range: WB:1:1,000 ICC:1:50-1:200

Background: Interferon regulatory factor-1 (IRF-1) and IRF-2 have been identified as novel DNA-binding factors that function as regulators of both type I interferon (interferon-α and β) and interferon-inducible genes. The two factors are structurally related, particularly in their N-terminal regions, which confer DNA binding specificity. In addition, both bind to the same sequence within the promoters of interferon-α and interferon-β genes. IRF-1 functions as an activator of interferon transcription, while IRF-2 binds to the same cis elements and represses IRF-1 action. IRF-1 and IRF-2 have been reported to act in a mutually antagonistic manner in regulating cell growth; overexpression of the repressor IRF-2 leads to cell transformation while concomitant overexpression of IRF-1 causes reversion. IRF-1 and IRF-2 are members of a larger family of DNA binding proteins that includes IRF-3, IRF-4, IRF-5, IRF-6, IRF-7, ISGF-3γ p48 and IFN consensus sequence-binding protein (ICSBP) .

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: IRF3 (Phospho-S386) polyclonal Antibody detects endogenous levels of IRF3 protein only when phosphorylated at S386.

Molecular Weight: 47 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: IRF-3, IRF3, IIAE7, Interferon regulatory factor 3, IRF 3, IRF-3, IRF3, IRF3, MGC94729,

Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Ser386 of human IRF3.

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: ProA affinity purified

Pathway: