Irisin, Active, human recombinant | 7852

Irisin is a recently discovered exercise-induced myokine, which is secreted by skeletal muscles and produced by cleavage of the FNDC5. Studies show that Irisin stimulates mitochondria uncoupling protein-1 (UCP-1; a regulator of thermogenic capability of brown fat) expression, so Irisin can upregulate white to brown fat conversion and improve systemic metabolism by increasing energy expenditure. Hence, Irisin is a potential new drug target in the study of metabolic disorders, such as obesity and type 2 diabetes mellitus (T2DM). Moreover, FNDC5-like receptors are conserved in vertebrates and critical for neuronal development.

7852 | Irisin Active human recombinant DataSheet

Biomolecule/Target: Irisin

Synonyms: Fibronectin Type III Domain-containing Protein 5, FNDC5 (cleaved); Fibronectin Type III Repeat-containing Protein 2, FRCP2 (cleaved).

Alternates names: CSF-3, MGI-1G, GM-CSF beta, Pluripoietin, Filgrastim, Lenograstim, G-CSF, MGC45931, GCSF.

Taglines: Activates beige fat cells

NCBI Gene ID #: 1440

NCBI Gene Symbol: CSF3

Gene Source: Human

Accession #: P09919

Recombinant: Yes

Source: Human 293 cell expressed

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: ED is typically 0.02 to 0.08 ng/mL. The specific activity was determined by the dose - Dependent stimulation of the proliferation of murine M-NFS-60 cells (Mouse Myeloid Leukemia indicator cell line).

Results: 0.02 to 0.08 ng/ml

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 21 to 25 kDa, monomer, glycosylated

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Lyophilized from PBS.

Reconstitution Instructions: Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.

Amino acid sequence: N/A