IRX3 polyclonal Antibody | BS61032

IRX3 polyclonal Antibody | BS61032 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: The Iroquois homeobox gene family of transcription factors regulate aspects of embryonic development including anterior/posterior and dorsal/ventral axis patterning in the central nervous system. The Iroquois family are clustered on two loci, IRXA and IRXB, which map to chromosomes 8 and 13 in mice. The IRXA group includes IRX, IRX2 and IRX4; the IRXB group comprises IRX3, IRX5 and IRX6. IRX1 and IRX2 are both widely expressed during development in the lung epithelium and also in the ventricular septum. IRX1 and IRX2 also play a role in digit formation (E11.5–E14.5) . The IRX gene family members are each expressed in a distinct pattern during mouse heart development. Specifically, IRX1 and IRX2 are expressed in the ventricular septum and IRX3 is expressed in the ventricular trabeculated myocardium. In addition, IRX4 is expressed in the linear heart tube and the AV canal; IRX5 is expressed in the endocardium lining the ventricular and atrial myocardium. Furthermore, the IRX4 gene may modulate cardiac development and function. Although the heart of IRX4 (-) mice appears to develop normally, adult IRX4 (-) mice exhibit cardiomyopathy, including cardiac hypertrophy and decreased contractility.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IRX3 polyclonal Antibody detects endogenous levels of IRX3 protein.

Molecular Weight: ~ 52 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Iroquois-class homeodomain protein IRX-3; Homeodomain protein IRXB1; Iroquois homeobox protein 3; IRX3; IRXB1

Immunogen: A synthetic peptide corresponding to residues in Human IRX3.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Signaling Pathways Activating p38 MAP Kinase,