ITIH3 polyclonal Antibody | BS60741

ITIH3 polyclonal Antibody | BS60741 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB

Application Range: WB: 1:500~1:1000

Background: The inter-α trypsin inhibitor (ITI) family is a group of structurally related plasma serine protease inhibitors synthesized in the liver and built up from different combinations of three highly homologous heavy chains (ITI-H1, ITI-H2 and ITI-H3) and one light chain (Bikunin) . A fourth member of the ITI family, ITI-H4 (also known as I α IH4P) harbors a Pro-rich region (PRR) in its C-terminus. ITI is a glycoprotein composed of three polypeptides linked by chondroitin sulphate: two heavy chains, ITI-H1 and ITI-H2, and Bikunin. Bikunin confers the protease-inhibitor function of ITI. The heavy chains of the ITI family, designated as SHAPs (for serum-derived hyaluronan-associated proteins),bind covalently to hyaluronic acid (HA), resulting in pericellular matrix stabilization. Although ITI-H1, ITI-H3 and Bikunin have antitumoral and antimetastatic properties in the cell, these proteins are also associated with malignant transformation of lung tissue. ITI-H3 and Bikunin associate to form pre-α-trypsin inhibitor (PαI), a serine-proteinase inhibitor found in human serum.ITI-H3 mRNA levels increase in response to IL-6.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: ITIH3 polyclonal Antibody detects endogenous levels of ITIH3 protein.

Molecular Weight: ~ 100 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Inter-alpha-trypsin inhibitor heavy chain H3; ITI heavy chain H3; ITI-HC3; Inter-alpha-inhibitor heavy chain 3; Serum-derived hyaluronan-associated protein; SHAP; ITIH3

Immunogen: A synthetic peptide corresponding to residues in Human ITIH3

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: