ITPK1 Antibody | 60-219

ITPK1 Antibody | 60-219 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Homology: Predicted species reactivity based on immunogen sequence: Bovine, Mouse

Immunogen: This ITPK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-54 amino acids from the N-terminal region of human ITPK1.

Research Area: Signal Transduction

Tested Application: WB

Application: For WB starting dilution is: 1:1000

Specificiy: N/A

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: 46 kDa

Validation: N/A

Isoform: N/A

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Clonality: Polyclonal

Clone: N/A

Isotype: Rabbit Ig

Conjugate: Unconjugated

Physical State: Liquid

Buffer: Supplied in PBS with 0.09% (W/V) sodium azide.

Concentration: batch dependent

Storage Condition: Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Alternate Name: Inositol-tetrakisphosphate 1-kinase, Inositol 1, 4-trisphosphate 5/6-kinase, Inositol-triphosphate 5/6-kinase, Ins (1, 4) P (3) 5/6-kinase, ITPK1

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Kinase that can phosphorylate various inositol polyphosphate such as Ins (3, 4, 5, 6) P4 or Ins (1, 3, 4) P3. Phosphorylates Ins (3, 4, 5, 6) P4 at position 1 to form Ins (1, 3, 4, 5, 6) P5. This reaction is thought to have regulatory importance, since Ins (3, 4, 5, 6) P4 is an inhibitor of plasma membrane Ca (2+) -activated Cl (-) channels, while Ins (1, 3, 4, 5, 6) P5 is not. Also phosphorylates Ins (1, 3, 4) P3 on O-5 and O-6 to form Ins (1, 3, 4, 6) P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins (1, 3, 4, 5) P4 and Ins (1, 3, 4, 6) P4 to Ins (1, 3, 4) P3, and Ins (1, 3, 4, 5, 6) P5 to Ins (3, 4, 5, 6) P4. May also act as an isomerase that interconverts the inositol tetraphosphate isomers Ins (1, 3, 4, 5) P4 and Ins (1, 3, 4, 6) P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain.