IWP-2 | 1962

Cell-permeable. Acts as an inhibitor of Wnt secretion and processing. It blocks Wnt-dependent signaling (IC₅₀ = 27 nM) by inhibition of the O-acyltransferase Porcn. Porcn is a member of the membrane-bound O-acyltransferase (MBOAT) family, which adds a palmitoyl group to Wnt proteins that is essential to their signaling ability and is required for Wnt secretion.

IWP-2 acts as an inhibitor of Wnt secretion and processing. It blocks Wnt-dependent signaling (IC₅₀ = 27 nM) by inhibition of the O-acyltransferase Porcn. Porcn is a member of the membrane-bound O-acyltransferase (MBOAT) family, which adds a palmitoyl group to Wnt proteins that is essential to their signaling ability and is required for Wnt secretion.

1962 | IWP-2 DataSheet

Alternate Name/Synonyms: N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide

Appearance: Beige solid

Formulation: N/A

CAS Number: 686770-61-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₁₈N₄O₃S₃

Molecular Weight: 466.6

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (~5 mg/ml with warming)

Handling: Protect from light and air

Country of Origin: USA

Tag Line: An inhibitor of Wnt secretion and processing

MDL Number: MFCD04457599

PubChem CID: 2155128

SMILES: CC1=CC2=C(C=C1)N=C(S2)NC(=O)CSC3=NC4=C(C(=O)N3C5=CC=CC=C5)SCC4

InChi: InChI=1S/C22H18N4O2S3/c1-13-7-8-15-17(11-13)31-21(23-15)25-18(27)12-30-22-24-16-9-10-29-19(16)20(28)26(22)14-5-3-2-4-6-14/h2-8,11H,9-10,12H2,1H3,(H,23,25,27)

InChi Key: WRKPZSMRWPJJDH-UHFFFAOYSA-N