JAG1 Antibody (C-term) [AMM06034G]

JAG1 Antibody (C-term) [AMM06034G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This JAG1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1190-1224 amino acids from the C-terminal region of human JAG1.

Cellular Localisation: Membrane; Single-pass type I membrane protein.

Molecular Weight: 133799

Clone: Polyclonal

Gene Name: JAG1

Gene ID: 182

Function: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (PubMed:18660822, PubMed:20437614) . May be involved in cell-fate decisions during hematopoiesis (PubMed:9462510) . Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity) . Enhances fibroblast growth factor-induced angiogenesis (in vitro) .

Summary: Tissue Location: Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Protein jagged-1, Jagged1, hJ1, CD339, JAG1, JAGL1