Jervine | 2357

Cell-permeable. Structurally similar to cyclopamine (Cat. No. 1578). Inhibits the sonic hedgehog (shh) pathway by interacting with smoothened. Jervine can be used to induce abnormal morphogenesis in a number of experimental models. Tomatidine (Cat. No. 1893) is a useful negative control.

Jervine is structurally similar to cyclopamine (Cat. No. 1578). Inhibits the sonic hedgehog (shh) pathway by interacting with smoothened.

2357 | Jervine DataSheet

Alternate Name/Synonyms: (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,1­1bR)-2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexad­ecahydro-3-hydroxy-3',6',10,11b-tetramethyl-Spiro[9H­-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1­H)-one

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 469-59-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₇H₃₉NO₃

Molecular Weight: 425.6

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (5 mg/ml) or EtOH (10 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A sonic hedgehog (Shh) pathway inhibitor

MDL Number: MFCD01684066

PubChem CID: 10098

SMILES: CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5C(=O)C4=C3C)C)O)C)NC1

InChi: InChI=1S/C27H39NO3/c1-14-11-21-24(28-13-14)16(3)27(31-21)10-8-19-20-6-5-17-12-18(29)7-9-26(17,4)23(20)25(30)22(19)15(27)2/h5,14,16,18-21,23-24,28-29H,6-13H2,1-4H3/t14-,16+,18-,19-,20-,21+,23+,24-,26-,27-/m0/s1

InChi Key: CLEXYFLHGFJONT-DNMILWOZSA-N