JH-II-127 | 9632

JH-II-127 is a highly potent, selective, and cell-permeable LRRK2 inhibitor, with IC₅₀ of 6.6 nM, 2.2 nM ,47.7 nM for LRRK2-wild-type, LRRK2-G2019S, LRRK2-A2016T. JH-II-127 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at a concentration of 0.1-0.3 μM in a variety of cell types and is capable of inhibiting Ser935 phosphorylation in mouse brain following oral delivery of doses as low as 30 mg/kg.

JH-II-127 is a highly potent, selective, and cell-permeable LRRK2 inhibitor, with IC₅₀ of 6.6 nM, 2.2 nM ,47.7 nM for LRRK2-wild-type, LRRK2-G2019S, LRRK2-A2016T. JH-II-127 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at a concentration of 0.1-0.3 μM in a variety of cell types and is capable of inhibiting Ser935 phosphorylation in mouse brain following oral delivery of doses as low as 30 mg/kg.

9632 | JH-II-127 DataSheet

Alternate Name/Synonyms: 4-((5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1700693-08-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₂₁ClN₆O₃

Molecular Weight: 416.87

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A highly potent, selective, and cell-permeable LRRK2 inhibitor

MDL Number: N/A

PubChem CID: N/A

SMILES: O=C(C1=CC=C(NC2=NC(NC)=C3C(NC=C3Cl)=N2)C(OC)=C1)N4CCOCC4

InChi: InChI=1S/C19H21ClN6O3/c1-21-16-15-12(20)10-22-17(15)25-19(24-16)23-13-4-3-11(9-14(13)28-2)18(27)26-5-7-29-8-6-26/h3-4,9-10H,5-8H2,1-2H3,(H3,21,22,23,24,25)

InChi Key: HUEKBQXFNHWTQQ-UHFFFAOYSA-N