JM6 | 1913

Cell-permeable. A slow-release prodrug version of Ro 61-8048 (Cat. No. 1912-5, 25), an inhibitor of KMO (kynurenine 3-monoxygenase), the enzyme that controls the kynurenine pathway, long believed to be implicated in neurodegeneration. JM6 reverses and prevents symptoms of neurodegenerative diseases like Alzheimer’s and Huntington’s in animal models. JM6 does not penetrate into the brain, but works by inhibiting KMO in the blood.

JM6 is a slow-release prodrug version of Ro 61-8048 (Cat. No. 1912-5, 25), an inhibitor of KMO (kynurenine 3-monoxygenase), the enzyme that controls the kynurenine pathway, long believed to be implicated in neurodegeneration. JM6 reverses and prevents symptoms of neurodegenerative diseases like Alzheimer’s and Huntington’s in animal models. JM6 does not penetrate into the brain, but works by inhibiting KMO in the blood.

1913 | JM6 DataSheet

Alternate Name/Synonyms: 2-(3,4-Dimethoxybenzenesulfonylamino)-4-(3-Nitrophenyl)-5-(Piperidin-1-yl)Methylthiazole

Appearance: Off-white solid

Formulation: N/A

CAS Number: N/A

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₂₆N₄O₆S₂

Molecular Weight: 518.61

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from light

Country of Origin: USA

Tag Line: A high-affinity inhibitor of KMO (kynurenine 3-monoxygenase or kynurenine 3-hydroxylase

MDL Number: MFCD22380618

PubChem CID: 24812126

SMILES: COC1=C(C=C(C=C1)S(=O)(=O)NC2=NC(=C(S2)CN3CCCCC3)C4=CC(=CC=C4)[N+](=O)[O-])OC

InChi: InChI=1S/C23H26N4O6S2/c1-32-19-10-9-18(14-20(19)33-2)35(30,31)25-23-24-22(16-7-6-8-17(13-16)27(28)29)21(34-23)15-26-11-4-3-5-12-26/h6-10,13-14H,3-5,11-12,15H2,1-2H3,(H,24,25)

InChi Key: AOZLMMDVJOGGEQ-UHFFFAOYSA-N