JNJ-1661010 | 2413

Cell-permeable. A potent , selective and reversible FAAH (Fatty Acid Amide Hydrolase) inhibitor. Initially forms a covalent adduct with FAAH but is slowly released, IC₅₀ = 12 nM. Displays100-fold selectivity for FAAH-1 over FAAH-2. Displays analgesic activity in various animal models.

JNJ-1661010 is a potent, selective and reversible FAAH (Fatty Acid Amide Hydrolase) inhibitor. Initially forms a covalent adduct with FAAH but is slowly released, IC₅₀ = 12 nM. Displays100-fold selectivity for FAAH-1 over FAAH-2.

2413 | JNJ-1661010 DataSheet

Alternate Name/Synonyms: 4-(3-Phenyl-[1,2,4]- thizdiazol-5-yl)-piperazine-1-carboxylic acid phenylamide

Appearance: Off-white solid

Formulation: N/A

CAS Number: 681136-29-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₉N₅OS

Molecular Weight: 365.46

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (~25 mg/ml)

Handling: Protect from light and air

Country of Origin: USA

Tag Line: A FAAH inhibitor

MDL Number: MFCD00209157

PubChem CID: 2809273

SMILES: C1CN(CCN1C2=NC(=NS2)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4

InChi: InChI=1S/C19H19N5OS/c25-18(20-16-9-5-2-6-10-16)23-11-13-24(14-12-23)19-21-17(22-26-19)15-7-3-1-4-8-15/h1-10H,11-14H2,(H,20,25)

InChi Key: BHBOSTKQCZEAJM-UHFFFAOYSA-N