JNJ-38877605 | B2063

JNJ-38877605 is a potent c-MET tyrosine kinase inhibitor with potential anti-neoplastic activity. It is potent (IC₅₀ values of 4 nM and 50 nM for c-MET enzyme and Phospho-MET respectively). Displays selectivity over 229 other kinases tested.

JNJ-38877605 is a potent c-MET tyrosine kinase inhibitor with potential anti-neoplastic activity. It is potent (IC₅₀ values of 4 nM and 50 nM for c-MET enzyme and Phospho-MET respectively). Displays selectivity over 229 other kinases tested.

B2063 | JNJ-38877605 DataSheet

Alternate Name/Synonyms: 6-(difluoro(6-(1-methyl-1H-pyrazol-3-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 943540-75-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₃F₂N₇

Molecular Weight: 377.35

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A novel c-Met tyrosine kinase inhibitor

MDL Number: N/A

PubChem CID: 46911863

SMILES: CN1C=C(C=N1)C2=NN3C(=NN=C3C(C4=CC5=C(C=C4)N=CC=C5)(F)F)C=C2

InChi: InChI=1S/C19H13F2N7/c1-27-11-13(10-23-27)16-6-7-17-24-25-18(28(17)26-16)19(20,21)14-4-5-15-12(9-14)3-2-8-22-15/h2-11H,1H3

InChi Key: JRWCBEOAFGHNNU-UHFFFAOYSA-N