JNJ-42041935 | B1072

JNJ-42041935 is a HIF-PHD (Hypoxia-inducible factor- prolyl hydroxylase) inhibitor. JNJ-42041935 is a selective, 2-OG (2-oxoglutarate) competitive, and reversible inhibitor of PHD enzymes (pKis = 7.91, 7.29, and 7.65 for PHD1, 2, and 3, respectively). It is >100-fold selective for PHD compared to the related FIH (factor-inhibiting HIF) and a panel of various other enzymes.

JNJ-42041935 is a HIF-PHD (Hypoxia-inducible factor- prolyl hydroxylase) inhibitor. JNJ-42041935 is a selective, 2-OG (2-oxoglutarate) competitive, and reversible inhibitor of PHD enzymes (pKis = 7.91, 7.29, and 7.65 for PHD1, 2, and 3, respectively). It is >100-fold selective for PHD compared to the related FIH (factor-inhibiting HIF) and a panel of various other enzymes.

B1072 | JNJ-42041935 DataSheet

Alternate Name/Synonyms: 1-[6-chloro-5-(trifluoromethoxy)-1H-benzimidazol-2-yl]-1H-pyrazole-4-carboxylic acid

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 1193383-09-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: no

Molecular Formula: C₁₂H₆ClF₃N₄O₃

Molecular Weight: 346.65

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective HIF-PHD inhibitor

MDL Number:

PubChem CID: 45102710

SMILES: C1=C2C(=CC(=C1Cl)OC(F)(F)F)N=C(N2)N3C=C(C=N3)C(=O)O

InChi: 1S/C12H6ClF3N4O3/c13-6-1-7-8(2-9(6)23-12(14,15)16)19-11(18-7)20-4-5(3-17-20)10(21)22/h1-4H,(H,18,19)(H,21,22)

InChi Key: FXHHASJVTYRJHH-UHFFFAOYSA-N