JNJ-64619178 | B3322

JNJ-64619178 is a selective and pseudo-irreversible protein arginine methyltransferase 5 (PRMT5) inhibitor (IC50 of 0.14 nM). It inhibits the growth of various cancer cells in vitro and reduces tumor growth in non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) mouse xenograft models.

JNJ-64619178 is a selective and pseudo-irreversible protein arginine methyltransferase 5 (PRMT5) inhibitor (IC50 of 0.14 nM). It inhibits the growth of various cancer cells in vitro and reduces tumor growth in non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) mouse xenograft models.

B3322 | JNJ-64619178 DataSheet

Alternate Name/Synonyms: Onametostat (1S,2R,3S,5R)-3-[2-(2-amino-3-bromo-7-quinolinyl)ethyl]-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1,2-cyclopentanediol

Appearance: Solid

Formulation:

CAS Number: 2086772-26-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₃BrN₆O₂

Molecular Weight: 483.36

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: >50 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent protein arginine methyltransferase 5 (PRMT5) inhibitor

MDL Number:

PubChem CID: 126637809

SMILES: C1C(C(C(C1N2C=CC3=C(N=CN=C32)N)O)O)CCC4=CC5=NC(=C(C=C5C=C4)Br)N

InChi: InChI=1S/C22H23BrN6O2/c23-15-8-12-3-1-11(7-16(12)28-21(15)25)2-4-13-9-17(19(31)18(13)30)29-6-5-14-20(24)26-10-27-22(14)29/h1,3,5-8,10,13,17-19,30-31H,2,4,9H2,(H2,25,28)(H2,24,26,27)/t13-,17+,18+,19-/m0/s1

InChi Key: DBSMLQTUDJVICQ-CJODITQLSA-N