JunD (Phospho-S255) polyclonal Antibody | BS94014

JunD (Phospho-S255) polyclonal Antibody | BS94014 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB ICC/IF IHC

Application Range: WB:1:1,000 ICC:1:50-1:200 IHC:1:50-1:200

Background: The activator protein-1 (AP-1) transcription factor consists of either Jun/Jun homodimers or Fos/Jun heterodimeric complexes. Homo- and heterodimers bind to the TGACTCA consensus sequence present in numerous promoters and initially identified as the phorbol ester tumor promoter response element (TRE) . Jun B and Jun D have been shown to be almost identical to c-Jun in their C-terminal regions, which are involved in dimerization and DNA binding, whereas their N-terminal domains, which are involved in transcriptional activation, diverge. All three form heterodimers among themselves and with c-Fos and other members of the Fos gene family. Studies suggest that the two forms of Jun D may be due to internal initiation of translation.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: JunD (Phospho-S255) polyclonal Antibody detects endogenous levels of JunD protein only when phosphorylated at S255.

Molecular Weight: 35 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: JUND, Activator protein 1, AP 1, AP1, Jun D, jun D proto oncogene, Jund, JunD FL isoform, JUND, Transcription factor jun D, Transcription factor jun-D,

Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Ser255 of human JunD.

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: ProA affinity purified

Pathway: TGFβ Smad signaling,