JZL-184 | B2755

JZL-184 is a potent and selective inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 8 nM and 4 µM for inhibition of MAGL and fatty acid amide hydrolase in mouse brain membranes, respectively. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function.

JZL-184 is a potent and selective inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 8 nM and 4 µM for inhibition of MAGL and fatty acid amide hydrolase in mouse brain membranes, respectively. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function.

B2755 | JZL-184 DataSheet

Alternate Name/Synonyms: JZL184,4-nitrophenyl-4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate

Appearance: Pale yellow to yellowish green solid

Formulation:

CAS Number: 1101854-58-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₇H₂₄N₂O

Molecular Weight: 242.66

Cell-Permeable?: TRUE

Purity: ≥95% by HPLC

Solubilities: ~10 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent and selective inhibitor of monoacylglycerol lipase (MAGL)

MDL Number: MFCD12912421

PubChem CID: 25021165

SMILES: OC(C1=CC(OCO2)=C2C=C1)(C3=CC=C(OCO4)C4=C3)C5CCN(C(OC6=CC=C([N+]([O-])=O)C=C6)=O)CC5

InChi: InChI=1S/C27H24N2O9/c30-26(38-21-5-3-20(4-6-21)29(32)33)28-11-9-17(10-12-28)27(31,18-1-7-22-24(13-18)36-15-34-22)19-2-8-23-25(14-19)37-16-35-23/h1-8,13-14,17,31H,9-12,15-16H2

InChi Key: SEGYOKHGGFKMCX-UHFFFAOYSA-N