K-604, ACAT-1 Inhibitor | B2926

K-604 is an inhibitor of acyl-CoA:cholesterol acyltransferase 1 (ACAT1). The IC₅₀ values of K-604 for human ACAT-1 and ACAT-2 are 0.45 μM and 102.85 μM respectively, showing that K-604 is 229-fold more selective for ACAT-1. It suppresses the development of atherosclerosis in an animal model without affecting plasma cholesterol levels. It stimulates collagen production in cultured smooth muscle cells and modulates plaque phenotype in apolipoprotein E-knockout mice.

K-604 is an inhibitor of acyl-CoA:cholesterol acyltransferase 1 (ACAT1). The IC₅₀ values of K-604 for human ACAT-1 and ACAT-2 are 0.45 μM and 102.85 μM respectively, showing that K-604 is 229-fold more selective for ACAT-1. It suppresses the development of atherosclerosis in an animal model without affecting plasma cholesterol levels. It stimulates collagen production in cultured smooth muscle cells and modulates plaque phenotype in apolipoprotein E-knockout mice.

B2926 | K-604, ACAT-1 Inhibitor DataSheet

Alternate Name/Synonyms: 2-(4-(2-(1H-benzo[d]imidazol-2-ylthio)ethyl)piperazin-1-yl)-N-(6-methyl-2,4-bis(methylthio)pyridin-3-yl)acetamide; 4-[2-(1H-Benzimidazol-2-ylthio)ethyl]-N-[6-methyl-2,4-bis(methylthio)-3-pyridinyl]-1-piperazineacetamide

Appearance: Solid

Formulation:

CAS Number: 561023-90-3

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₂₃H₃₀N₆OS₃

Molecular Weight: 502.72

Cell-Permeable?: True

Purity: 95%

Solubilities: Soluble in DMSO in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of ACAT1

MDL Number:

PubChem CID: 9892288

SMILES: CC1=CC(=C(C(=N1)SC)NC(=O)CN2CCN(CC2)CCSC3=NC4=CC=CC=C4N3)SC

InChi: InChI=1S/C23H30N6OS3/c1-16-14-19(31-2)21(22(24-16)32-3)27-20(30)15-29-10-8-28(9-11-29)12-13-33-23-25-17-6-4-5-7-18(17)26-23/h4-7,14H,8-13,15H2,1-3H3,(H,25,26)(H,27,30)

InChi Key: VGGMTOYKEDKFLN-UHFFFAOYSA-N