K858 | B1073

K858 is a selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor (IC₅₀ = 1.3 µM) and an antitumor agent. Induces cell death in cancer cells, blocks centrosome separation, activates the spindle checkpoint, and induces mitotic arrest in cells accompanied by the formation of monopolar spindles.

K858 is a selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor (IC₅₀ = 1.3 µM) and an antitumor agent. Induces cell death in cancer cells, blocks centrosome separation, activates the spindle checkpoint, and induces mitotic arrest in cells accompanied by the formation of monopolar spindles.

B1073 | K858 DataSheet

Alternate Name/Synonyms: N-(4-acetyl-5-methyl-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamide

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 72926-24-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₃H₁₅N₃O₂S

Molecular Weight: 277.34

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor

MDL Number: MFCD00181155

PubChem CID: 2930014

SMILES: CC(=O)NC1=NN(C(S1)(C)C2=CC=CC=C2)C(=O)C

InChi: InChI=1S/C13H15N3O2S/c1-9(17)14-12-15-16(10(2)18)13(3,19-12)11-7-5-4-6-8-11/h4-8H,1-3H3,(H,14,15,17)

InChi Key: JEFVYQYZCAVNTP-UHFFFAOYSA-N