KANK2 Antibody (Center) [APR33308G]

KANK2 Antibody (Center) [APR33308G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This KANK2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 343-376 amino acids from the Central region of human KANK2.

Cellular Localisation: Cytoplasm. Mitochondrion

Molecular Weight: 91174

Clone: Polyclonal

Gene Name: KANK2

Gene ID: 25959

Function: Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305) . Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500) . Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500) . Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081) . Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457) . May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457) . Through the Rho signaling pathway may also regulate cell proliferation (By similarity) .

Summary: Tissue Location: Strongly expressed in cervix, colon, heart, kidney and lung. Expressed in kidney glomerular podocytes and mesangial cells (at protein level) .

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: KN motif and ankyrin repeat domain-containing protein 2, Ankyrin repeat domain-containing protein 25, Matrix-remodeling-associated protein 3, SRC-1-interacting protein, SIP, SRC-interacting protein, SRC1-interacting protein, KANK2, ANKRD25, KIAA1518, MXRA3, SIP