KC7F2 | 9641

KC7F2 is a small molecule HIF-1 pathway inhibitor that inhibits HIF-1α protein translation, but not transcription. It inhibits hypoxia-induced expression of several HIF target genes, such as carbonic anhydrase IX, matrix metalloproteinase 2, enolase 1, and endothelin 1. KC7F2 is cytotoxic to a variety of cancer cell lines with an IC₅₀ value of 15-25 µM.

KC7F2 is a small molecule HIF-1 pathway inhibitor that inhibits HIF-1α protein translation, but not transcription. It inhibits hypoxia-induced expression of several HIF target genes, such as carbonic anhydrase IX, matrix metalloproteinase 2, enolase 1, and endothelin 1. KC7F2 is cytotoxic to a variety of cancer cell lines with an IC₅₀ value of 15-25 µM.

9641 | KC7F2 DataSheet

Alternate Name/Synonyms: N,N'-(dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonamide

Appearance: White solid

Formulation: N/A

CAS Number: 927822-86-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₁₆Cl₄N₂O₄S₄

Molecular Weight: 570.38

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>50 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A small molecule HIF-1 pathway inhibitor

MDL Number: N/A

PubChem CID: 16047442

SMILES: C1=CC(=C(C=C1Cl)S(=O)(=O)NCCSSCCNS(=O)(=O)C2=C(C=CC(=C2)Cl)Cl)Cl

InChi: InChI=1S/C16H16Cl4N2O4S4/c17-11-1-3-13(19)15(9-11)29(23,24)21-5-7-27-28-8-6-22-30(25,26)16-10-12(18)2-4-14(16)20/h1-4,9-10,21-22H,5-8H2

InChi Key: REQLACDIZMLXIC-UHFFFAOYSA-N