KCNMA1 Antibody (N-Term) [APR08081G]

KCNMA1 Antibody (N-Term) [APR08081G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This KCNMA1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 118-152 amino acids from human KCNMA1.

Cellular Localisation: Cell membrane; Multi-pass membrane protein

Molecular Weight: 137560

Clone: Polyclonal

Gene Name: KCNMA1 (HGNC:6284)

Gene ID: 3778

Function: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca (2+) that mediates export of K (+) (PubMed:29330545, PubMed:31152168) . It is also activated by the concentration of cytosolic Mg (2+) . Its activation dampens the excitatory events that elevate the cytosolic Ca (2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca (2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX) .

Summary: Tissue Location: Widely expressed. Except in myocytes, it is almost ubiquitously expressed.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:500

Synonyms: Calcium-activated potassium channel subunit alpha-1, BK channel, BKCA alpha, Calcium-activated potassium channel, subfamily M subunit alpha-1, K (VCA) alpha, KCa11, Maxi K channel, MaxiK, Slo-alpha, Slo1, Slowpoke homolog, Slo homolog, hSlo, KCNMA1, KCNMA, SLO