KCTD21 Antibody (C-term) [APR14120G]

KCTD21 Antibody (C-term) [APR14120G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This KCTD21 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 232-260 amino acids from the C-terminal region of human KCTD21.

Cellular Localisation: N/A

Molecular Weight: 29643

Clone: Polyclonal

Gene Name: KCTD21

Gene ID: 283219

Function: Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142) .

Summary: Tissue Location: Highly expressed in cerebellum and brain. Expression is down-regulated in medulloblastoma

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, FC

Dilution: WB--1:1000 IHC-P--1:100~500 FC--1:10~50

Synonyms: BTB/POZ domain-containing protein KCTD21, KCTD21