KDM3B Polyclonal Antibody | E-AB-11339

KDM3B Polyclonal Antibody | E-AB-11339 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: 5qNCA, C5orf7, JHDM2B, JmjC domain containing histone demethylation protein 2B, JmjC domain-containing histone demethylation protein 2B, jmjd1b, Jumonji domain containing 1B, Jumonji domain containing protein 1B, Jumonji domain-containing protein 1B, KDM3B, KDM3B, KIAA1082, Lysine (K) specific demethylase 3B, Lysine-specific demethylase 3B, NET22, Nuclear protein 5qNCA

Application: WB, IHC, ELISA

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Epigenetics and Nuclear Signaling

Background: JMJD1B (jumonji domain containing 1B), also known as KDM3B, 5qNCA (5q Nuclear Co-Activator) or C5orf7, is a member of the JHDM2 histone demethylase family of proteins. Expressed in a wide variety of tissues, JMJD1B localizes to the nucleus and contains one JMJC domain and a C-terminal zinc finger motif. JMJD1B functions as a histone demethylase and, using iron as a cofactor, demethylates lysine-9 of Histone H3. This suggests that JMJD1B plays a central role in the histone code. The gene encoding human JMJD1B is located within the 5q region of the genome that is often deleted in myeloid leukemias and myelodysplasias. This implies that JMJD1B may function as a tumor suppressor of myeloid leukemia. Eptopic expression of JMJD1B exhibits growth suppressive activities, further supporting a role for JMJD1B in tumor suppression.

Concentration: 0.4 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant protein of human KDM3B

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification Method: Affinity purification

Dilution: WB 1:1000-1:5000, IHC 1:50-1:200

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 192 kDa

Molecular Weight(Observed): N/A