KDM5B polyclonal Antibody | BS70906

KDM5B polyclonal Antibody | BS70906 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB IF

Application Range: WB 1:500 - 1:2000 IF 1:50 - 1:200

Background: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: KDM5B polyclonal Antibody detects endogenous levels of KDM5B protein.

Molecular Weight: ~ 176 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Lysine-specific demethylase 5B; Cancer/testis antigen 31; CT31; PLU-1; RBP2-H1; JARID1B; PLU1; RBBP2H1

Immunogen: Recombinant protein of human KDM5B.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Vesicle Trafficking presynaptic signaling,