KHS-101 | B2415

KHS-101 is a selective inducer of neuronal differentiation. It induces neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs) by interacting with TACC3 (EC50 ~1 μM). Also induces acceleration of neuronal differentiation in the hippocampal dentate gyrus in vivo. Additionally, it disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice.

KHS-101 is a selective inducer of neuronal differentiation. It induces neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs) by interacting with TACC3 (EC50 ~1 μM). Also induces acceleration of neuronal differentiation in the hippocampal dentate gyrus in vivo. Additionally, it disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice.

B2415 | KHS-101 DataSheet

Alternate Name/Synonyms: N4-isobutyl-N2-((2-phenylthiazol-4-yl)methyl)pyrimidine-2,4-diamine

Appearance: Off-white solid

Formulation:

CAS Number: 1262770-73-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₂₁N₅S

Molecular Weight: 339.46

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: Neuronal differentiation inducer

MDL Number: MFCD18206916

PubChem CID: 71304818

SMILES: CC(C)CNC1=NC(=NC=C1)NCC2=CSC(=N2)C3=CC=CC=C3

InChi: InChI=1S/C18H21N5S/c1-13(2)10-20-16-8-9-19-18(23-16)21-11-15-12-24-17(22-15)14-6-4-3-5-7-14/h3-9,12-13H,10-11H2,1-2H3,(H2,19,20,21,23)

InChi Key: DGRJOOOHPBSAHD-UHFFFAOYSA-N