KLF17 Antibody | 8041

KLF17 Antibody | 8041 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: Predicted species reactivity based on immunogen sequence: Pig: (81%) , Chicken: (79%)

Immunogen: KLF17 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human KLF17.
The immunogen is located within the last 50 amino acids of KLF17.

Research Area: Cancer

Tested Application: E, WB, IHC-P

Application: KLF17 antibody can be used for detection of KLF17 by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in rat samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.

Specificiy: KLF17 antibody is human, mouse and rat reactive. At least two isoforms of KLF17 are known to exist; this antibody will only detect the large isoform. KLF17 antibody is predicted to not cross-react with other KLF proteins.

Positive Control 1: Cat. No. 1464 - Rat Liver Tissue Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 28, 39, 43 kDa
Observed: 38 kDa

Validation: N/A

Isoform: N/A

Purification: KLF17 antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: KLF17 antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: KLF17 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: Kruppel-like factor 17, zinc finger protein 393, ZNF393, Zfp393

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: KLF17, also known as ZNF393, is a member of the Sp/KLF family of transcription factors (1, 2) . KLF17 binds to the promoter and negatively regulates the transcription of Id-1, a key metastasis regulator in breast cancer (3) . Suppression of KLF17 promotes breast cancer cell invasion and epithelial-mesenchymal transition (3) . Down-regulated KLF17 expression is also associated tumor invasion and poor prognosis in hepatocellular carcinoma, suggesting that the level of KLF17 expression can serve as a prognostic indicator (4) .