KMO Antibody (Center) [APR08111G]

KMO Antibody (Center) [APR08111G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This KMO antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 155-182 amino acids from the Central region of human KMO.

Cellular Localisation: Mitochondrion outer membrane {ECO:0000255|HAMAP- Rule:MF_03018, ECO:0000269|PubMed:9237672}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03018, ECO:0000269|PubMed:9237672}

Molecular Weight: 55810

Clone: Polyclonal

Gene Name: KMO {ECO:0000255|HAMAP-Rule:MF_03018, ECO:0000312|HGNC:HGNC:6381}

Gene ID: 8564

Function: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn) (PubMed:29429898, PubMed:23575632, PubMed:26752518, PubMed:28604669, PubMed:29208702) . Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (Probable) .

Summary: Tissue Location: Highest levels in placenta and liver. Detectable in kidney.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, FC

Dilution: WB--1:2000

Synonyms: Kynurenine 3-monooxygenase {ECO:0000255|HAMAP-Rule:MF_03018}, 114139 {ECO:0000255|HAMAP-Rule:MF_03018}, Kynurenine 3-hydroxylase {ECO:0000255|HAMAP-Rule:MF_03018}, KMO