KN-62 | 2495

Cell-permeable. KN-62 is a selective inhibitor of Ca²⁺/calmodulin-dependent kinase type II (CaMKII; IC₅₀= 900 nM). It binds directly to the calmodulin binding site of the enzyme. It does not affect the activity of several other kinases when tested at 10 µM. KN-62 also acts as a non-competitive antagonist of the purinergic receptor P2RX7 (IC₅₀ = 15 nM).

KN-62 is a selective inhibitor of Ca²⁺/calmodulin-dependent kinase type II (CaMKII; IC₅₀ = 900 nM). It binds directly to the calmodulin binding site of the enzyme. It does not affect the activity of several other kinases when tested at 10 µM.

2495 | KN-62 DataSheet

Alternate Name/Synonyms: 4-​[(2S)-​2-​[(5-​isoquinolinylsulfonyl)methylamino]-​3-​oxo-​3-​(4-​phenyl-​1-​piperazinyl)propyl]phenyl ester,​ 5-​isoquinolinesulfonic acid

Appearance: Pale yellow solid

Formulation: N/A

CAS Number: 127191-97-3

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₈H₃₅N₅O₆S₂

Molecular Weight: 721.84

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (>50 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective inhibitor of Ca²⁺/calmodulin-dependent kinase type II

MDL Number: MFCD00083180

PubChem CID: 5312126

SMILES: CN(C(CC1=CC=C(C=C1)OS(=O)(=O)C2=CC=CC3=C2C=CN=C3)C(=O)N4CCN(CC4)C5=CC=CC=C5)S(=O)(=O)C6=CC=CC7=C6C=CN=C7

InChi: InChI=1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3/t35-/m0/s1

InChi Key: RJVLFQBBRSMWHX-DHUJRADRSA-N