KRAS Polyclonal Antibody | E-AB-40187

KRAS Polyclonal Antibody | E-AB-40187 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: c Ki ras2, c Kirsten ras protein, c-K-ras, c-Ki-ras, Cellular c Ki ras2 proto oncogene, Cellular transforming proto oncogene, CFC2, cK Ras, GTPase KRas, K RAS p21 protein, K RAS2A, K RAS2B, K RAS4A, K RAS4B, K-Ras 2, KI RAS, Ki-Ras, KIRSTEN MURINE SARCOMA VIRUS 2, Kirsten rat sarcoma 2 viral (v Ki ras2) oncogene homolog, Kirsten rat sarcoma viral oncogene homolog, KRAS, KRAS proto oncogene, GTPase, KRAS1, KRAS2, N-terminally processed, NS, NS3, Oncogene KRAS2, p21ras, PR310 c K ras oncogene, PR310 cK ras oncogene, RALD, RASK, RASK2, Transforming protein p21, v Ki ras2 Kirsten rat sarcoma 2 viral oncogene homolog, v Ki ras2 Kirsten rat sarcoma viral oncogene homolog

Application: WB

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Epigenetics and Nuclear Signaling, Signal Transduction

Background: KRAS, also called p21, is a member of the Ras superfamily of proteins. It is located on human chromosome 12, and contains four coding exons and a 5' non-coding exon (PMID: 12778136). KRAS is a membrane-anchored guanosine triphosphate/guanosine diphosphate (GTP/GDP)-binding protein and is widely expressed in most human cells. Like other members of the Ras family, the KRAS protein is a GTPase, and it is involved in intracellular signal transduction and mainly responsible for EGFR-signaling activation (PMID: 19117687). KRAS mutations have been found in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. KRAS has two isoforms, a and b.

Concentration: 2 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant Human GTPase KRas protein

Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 21 kDa

Molecular Weight(Observed): 21 kDa