KSHVORF62 Antibody [5B7B6] | 32-229

KSHVORF62 Antibody [5B7B6] | 32-229 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Virus

Homology: N/A

Immunogen: Ni-NTA purified recombinant human KSHV ORF62 expressed in E. Coli strain BL21 (DE3) .

Research Area: Infectious Disease

Tested Application: WB

Application: Western Blot:1:500 - 1, 000
ELISA:Determining optimal working dilutions by titration test.

Specificiy: N/A

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: N/A

Clonality: Monoclonal

Clone: 5B7B6

Isotype: IgM

Conjugate: Unconjugated

Physical State: N/A

Buffer: Ascitic fluid containing 0.03% sodium azide.

Concentration: N/A

Storage Condition: to KSHV ORF62 monoclonal antibody can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Alternate Name: Triplex capsid protein VP19C homolog

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma- (2) -herpesvirus subfamily and has been closely linked to the Kaposi’s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. At least five major proteins are likely to be involved in the assembly of the HHV-8 capsid, including a protease (encoded by ORF17) , the major capsid protein (encoded by ORF25) , and three other smaller capsid proteins (encoded by ORF62, ORF26, and ORF65) . Previous structural studies have shown that the HSV-1 triplex is a monomer of VP19c and a dimer of VP23 and that the HCMV triplex is similarly composed of a monomer and a dimer. By analogy, the KSHV triplexes are likely also composed of a monomer of the ORF62 protein and a dimer of the ORF26 protein, which are the respective homologs of VP19c and VP23.