Ksr2 (I694) polyclonal Antibody | BS2321

Ksr2 (I694) polyclonal Antibody | BS2321 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC IF

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background: Kinase suppressor of Ras (Ksr) and MAP kinase kinase kinase (MEKK3) are integral members of the MAP kinase pathway. Ksr is a conserved protein that positively regulates Ras signaling and may function as a scaffold for Raf, MEK and ERK. There are two types of Ksr proteins: Ksr-1 and Ksr-2. Ksr-2 plays a key role in Ras-mediated signaling during germline meiotic progression and functions redundantly with Ksr-1 during the development of the excretory system pathway, hermaphrodite vulva, and male spicules. Ksr-2 also functions as a negative regulator of the MEKK3-mediated activation of the MAP kinase pathways (specifically ERK and JNK) and of the NF˚B pathways, and it simultaneously inhibits MEKK3-mediated Il-8 production.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Ksr2 (I694) polyclonal Antibody detects endogenous levels of Ksr2 protein.

Molecular Weight: ~ 108 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: KSR2; Kinase suppressor of Ras 2

Immunogen: Synthetic peptide, corresponding to amino acids 662-724 of Human Ksr2.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: hippo Signaling,