KW-2449 hydrochloride | B1208

KW 2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase. It displays potent inhibition of growth effects on leukemia cells with FLT3 mutations via inhibition of the FLT3 kinase. This leads in the down-regulation of phosphorylated-FLT3/STAT5, G1 arrest, and apoptosis. KW 2449 induces the reduction of phosphorylated histone H3, G2/M arrest, and apoptosis in FLT3 wild-type human leukemia.

KW 2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase. It displays potent inhibition of growth effects on leukemia cells with FLT3 mutations via inhibition of the FLT3 kinase. This leads in the down-regulation of phosphorylated-FLT3/STAT5, G1 arrest, and apoptosis. KW 2449 induces the reduction of phosphorylated histone H3, G2/M arrest, and apoptosis in FLT3 wild-type human leukemia.

B1208 | KW-2449 hydrochloride DataSheet

Alternate Name/Synonyms: [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone

Appearance: Crystalline Solid

Formulation: N/A

CAS Number: 1000669-72-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: Yes

Molecular Formula: C₂₀H₂₀N₄O. HCl

Molecular Weight: 368.86

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO(>30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase

MDL Number: MFCD18385006

PubChem CID: 11427553

SMILES: C1CN(CCN1)C(=O)C2=CC=C(C=C2)C=CC3=NNC4=CC=CC=C43

InChi: InChI=1S/C20H20N4O/c25-20(24-13-11-21-12-14-24)16-8-5-15(6-9-16)7-10-19-17-3-1-2-4-18(17)22-23-19/h1-10,21H,11-14H2,(H,22,23)/b10-7+

InChi Key: YYLKKYCXAOBSRM-JXMROGBWSA-N