L-α-Hydroxyglutaric Acid Disodium Salt | B2812

L-α-Hydroxyglutaric Acid is metabolized to 2-oxoglutarate or α-ketoglutarate by L-2-hydroxyglutarate dehydrogenase. Rare defects in L-2-hydroxyglutarate dehydrogenase cause a neurometabolic disorder characterized by 2-hydroxyglutaric aciduria. High concentrations of L-α-Hydroxyglutaric Acid inhibit histone lysine demethylases, which might promote oncogenesis. 2-hydroxyglutarate can be used in the collection buffer to improve HIF-1α recovery from tumor specimens.

L-α-Hydroxyglutaric Acid is metabolized to 2-oxoglutarate or α-ketoglutarate by L-2-hydroxyglutarate dehydrogenase. Rare defects in L-2-hydroxyglutarate dehydrogenase cause a neurometabolic disorder characterized by 2-hydroxyglutaric aciduria. High concentrations of L-α-Hydroxyglutaric Acid inhibit histone lysine demethylases, which might promote oncogenesis. 2-hydroxyglutarate can be used in the collection buffer to improve HIF-1α recovery from tumor specimens.

B2812 | L-α-Hydroxyglutaric Acid Disodium Salt DataSheet

Alternate Name/Synonyms: disodium;(2S)-2-hydroxypentanedioate, Sodium (S)-2-hydroxypentanedioate, Disodium (S)-2-hydroxyglutarate, (S)-2-Hydroxypentanedioic acid disodium salt

Appearance: Crystalline solid

Formulation:

CAS Number: 63512-50-5

Structure Available?: True

Peptide sequence:

Salt Form: True

Molecular Formula: C₅H₆Na₂O₅

Molecular Weight: 192.08

Cell-Permeable?: True

Purity: ≥95%

Solubilities: ~10 mg/ml in PBS in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: L-α-Hydroxyglutaric Acid increases in 2-hydroxyglutaric aciduria.

MDL Number:

PubChem CID: 56845267

SMILES: C(CC(=O)[O-])C(C(=O)[O-])O.[Na+].[Na+]

InChi: InChI=1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1/p-2/t3-;;/m0../s1

InChi Key: DZHFTEDSQFPDPP-QTNFYWBSSA-L