Lactacystin (Synthetic) | 1709

Cell-permeable. A potent and selective inhibitor of the 20 S proteasome. Binds irreversibly to the active site N-terminal threonine residue of the catalytic β-subunit of the 20S proteasome, thereby inhibiting its chymotrypsin and trypsin-like activities. Induces neurite outgrowth in Neuro 2A neuroblastoma cells and has been reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-kB activation (IC₅₀ = 10 µM).

Lactacystin is a potent and selective inhibitor of the 20 S proteasome. Binds irreversibly to the active site N-terminal threonine residue of the catalytic β-subunit of the 20S proteasome, thereby inhibiting its chymotrypsin and trypsin-like activities.

1709 | Lactacystin (Synthetic) DataSheet

Alternate Name/Synonyms: 2-(acetylamino)-3-[({3-hydroxy-2-[1-hydroxy-2-methylpropyl]-4-methyl-5-oxopyrrolidin-2-yl}carbonyl)sulfanyl]propanoic acid

Appearance: White solid

Formulation: N/A

CAS Number: 133343-34-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₂₄N₂O₇S

Molecular Weight: 376.42

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO (25 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A proteasome inhibitor

MDL Number: MFCD01076525

PubChem CID: 3870

SMILES: CC1C(C(NC1=O)(C(C(C)C)O)C(=O)SCC(C(=O)O)NC(=O)C)O

InChi: InChI=1S/C15H24N2O7S/c1-6(2)10(19)15(11(20)7(3)12(21)17-15)14(24)25-5-9(13(22)23)16-8(4)18/h6-7,9-11,19-20H,5H2,1-4H3,(H,16,18)(H,17,21)(H,22,23)

InChi Key: DAQAKHDKYAWHCG-UHFFFAOYSA-N