LAG3 Detection Set | SD8700

LAG3 Detection Set | SD8700 | Gentaur UK, US & Europe Distribution

Host: llama

Reactivity: Human

Homology: N/A

Immunogen: LAG3 antibodies were raised against a recombinant protein corresponding to amino acids 23-434 of human LAG3.

Tested Application: E, IHC-P, IF, Flow

Application: N/A

Specificity: N/A

Purification: LAG3 Antibodies are affinity chromatography purified via Nickel column. Antibodies are supplied as a His-tagged purified protein.  They also contains a myc-tag for detection.

Clonality: Monoclonal

Isotype: sdab

Conjugate: Unconjugated

Physical State: Liquid

Buffer: LAG3 Antibodies are supplied in PBS.

Concentration: Antibody 1 mg/mL

Storage Condition: LAG3 antibodies should be stored in working aliquots at -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Background: The lymphocyte activation gene-3 (LAG3) is a member of the immunoglobulin superfamily and binds MHC class II with high affinity (1), negatively regulating T-cell function and homeostasis (2). It is expressed in B, T, and NK cells, monocytes, and dendritic cells (3), and acts to regulate T cell expansion (4). LAG3 is also an important immune checkpoint protein, with anti-LAG3 antibodies activating T effector cells and affecting regulatory T cell functions. Furthermore LAG3 appears to act in a synergistic fashion with PD-1/PD-L1, suggesting that a dual antibody approach may prove useful in cancer immunotherapy.

User Note: Optimal dilutions for each application to be determined by the researcher.