Lamin B Receptor Polyclonal Antibody | BS65905

Lamin B Receptor Polyclonal Antibody | BS65905 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat,Cow,Horse,Rabbit,

Application: WB,

Application Range: WB=1:500-2000

Background: Lamins are nuclear membrane proteins that serve to maintain specific cellular functions, such as DNA replication and chromatin organization. Lamin B receptor (LBR) is an integral protein of the nuclear envelope inner membrane. It is phosphorylated by CDC2 protein kinase in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina and the chromatin. It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures. The cleavage of lamins results in nuclear disregulation and cell death.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Lamin B Receptor Polyclonal Antibody detects endogenous levels of Lamin B Receptor protein.

Molecular Weight: 68 kD

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: LBR_HUMAN; LMN2R; PHA; DHCR 14B; DHCR14B Antibody Integral nuclear envelope inner membrane protein; Lamin-B receptor; LBR; LMN 2R; LMN2R; MGC9041; PHA; PRO0650; DHCR14B; MGC9041.

Immunogen: KLH conjugated synthetic peptide derived from human Lamin B Receptor:1-100/615

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: affinity purified by Protein A

Pathway: