Lamin B1 Polyclonal Antibody | E-AB-40257

Lamin B1 Polyclonal Antibody | E-AB-40257 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: ADLD, lamin B1, Lamin-B1, LMN, LMN2, LMNB,Lmnb1,LMNB1,MGC111419, OTTHUMP00000159218

Application: WB, IHC, IF

Reactivity: Human, Rat, Mouse

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Cell Biology, Signal Transduction, Tags and Cell Markers

Background: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD).

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant Rat Lamin-B1 protein

Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.

Purification Method: Antigen Affinity Purification

Dilution: WB 1:1000-1:2000 IHC 1:100-1:200

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 67 kDa

Molecular Weight(Observed): 72 kDa