LASS6 Antibody (C-term) [APR31568G]

LASS6 Antibody (C-term) [APR31568G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This LASS6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 335-361 amino acids from the C-terminal region of human LASS6.

Cellular Localisation: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8C172}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8C172}

Molecular Weight: 44890

Clone: Polyclonal

Gene Name: CERS6 (HGNC:23826)

Gene ID: 253782

Function: Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) (PubMed:17977534, PubMed:17609214, PubMed:23530041, PubMed:26887952, PubMed:31916624) . Can use other acyl donors, but with less efficiency (By similarity) . N- acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (PubMed:17977534, PubMed:23530041, PubMed:26887952, PubMed:31916624) . Ceramides generated by CERS6 play a role in inflammatory response (By similarity) . Acts as a regulator of metabolism and hepatic lipid accumulation (By similarity) . Under high fat diet, palmitoyl- (C16:0-) ceramides generated by CERS6 specifically bind the mitochondrial fission factor MFF, thereby promoting mitochondrial fragmentation and contributing to the development of obesity (By similarity) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Ceramide synthase 6, CerS6, LAG1 longevity assurance homolog 6, CERS6, LASS6