Latrunculin A | 2181

A cell-permeable marine toxin. Disrupts microfilament-mediated processes. Actin polymerization inhibitor in vitro and in vivo by the formation of a 1:1 complex with monomeric G-actin. Depolymerizes actin filaments (F-actin) and acts as a phagocytosis inhibitor. Anticancer compound. Suppresses hypoxia-induced HIF-1 activation in tumor cells. Inhibits tumor cell invasion.

Latrunculin A is a cell-permeable marine toxin that disrupts microfilament-mediated processes. Actin polymerization inhibitor in vitro and in vivo by the formation of a 1:1 complex with monomeric G-actin.

2181 | Latrunculin A DataSheet

Alternate Name/Synonyms: LAT-A; NSC 613011

Appearance: White to light yellow solid

Formulation: N/A

CAS Number: 76343-93-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₃₁NO₅S

Molecular Weight: 421.55

Cell-Permeable?: Yes

Purity: ≥96% by HPLC

Solubilities: DMSO or EtOH

Handling: Protect from air and light

Country of Origin: USA

Tag Line: Actin polymerization inhibitor

MDL Number: MFCD00272613

PubChem CID: 6437378

SMILES: CC1CCC2CC(CC(O2)(C3CSC(=O)N3)O)OC(=O)C=C(CCC=CC=C1)C

InChi: InChI=1S/C22H31NO5S/c1-15-7-5-3-4-6-8-16(2)11-20(24)27-18-12-17(10-9-15)28-22(26,13-18)19-14-29-21(25)23-19/h3-5,7,11,15,17-19,26H,6,8-10,12-14H2,1-2H3,(H,23,25)/b4-3-,7-5+,16-11+/t15-,17-,18-,19+,22-/m1/s1

InChi Key: DDVBPZROPPMBLW-VREWCFMQSA-N