LBP, human recombinant | 4935

Natural LBP is a 58 kDa glycoprotein produced in liver. It binds at lipid A of LPS with high affinity (10-9M) and reduced the cellular LPS effects at CD14+ cells (IL1ß, IL6, TNF). It acts as opsonin for GRAM negative cells, LPS, neutrophils and granulocytes. This is a His-tagged protein.

4935 | LBP human recombinant DataSheet

Biomolecule/Target: N/A

Synonyms: Lipopolysaccharide-binding protein, LBP, LBP human recombinant protein, LBP human, human LBP

Alternates names: Lipopolysaccharide-binding protein, LBP, LBP human recombinant protein, LBP human, human LBP

Taglines: Elicits immune responses by presenting LPS

NCBI Gene ID #: 6354

NCBI Gene Symbol: MCP3

Gene Source: Human

Accession #: P80098

Recombinant: Yes

Source: CHO cells

Purity by SDS-PAGEs: 99%

Assay: SDS-PAGE

Purity: N/A

Assay #2: HPLC

Endotoxin Level: <0.03 ng/ ml

Activity (Specifications/test method): N/A

Biological activity: The human MCP-3 produced a 10-fold increase in chemotaxis at 100 ng/ml compared to the medium control in an assay using differentiated HL-60 cells plated on a primary endothelial cell layer.

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 58.0 kDa

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: Lyophilized from a concentrated protein solution (0.25 mg/ml) containing PBS, pH 7.1

Reconstitution Instructions: Reconstitute in HO to a concentration of 0.1 mg/ml. This solution can be diluted into other buffered solutions or stored at –20°C for future use.

Amino acid sequence: N/A