LEF1 Antibody [AMM22262G]

LEF1 Antibody [AMM22262G] | Gentaur UK, US & Europe Distribution

Product Category: Monoclonal Antibodies

Host: Mouse

Species Reactivity: H

Specificity: This antibody is generated from a mouse immunized with a recombinant protein between 95-283 amino acids from human.

Cellular Localisation: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}. Note=Found in nuclear bodies upon PIASG binding.

Molecular Weight: 44201

Clone: Monoclonal

Gene Name: LEF1

Gene ID: 51176

Function: Transcription factor that binds DNA in a sequence-specific manner (PubMed:2010090) . Participates in the Wnt signaling pathway (By similarity) . Activates transcription of target genes in the presence of CTNNB1 and EP300 (By similarity) . PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity) . TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 (PubMed:11266540) . Regulates T-cell receptor alpha enhancer function (PubMed:19653274) . Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regulator loci of BLK to modulate expression (By similarity) . May play a role in hair cell differentiation and follicle morphogenesis (By similarity) .

Summary: Tissue Location: Detected in thymus. Not detected in normal colon, but highly expressed in colon cancer biopsies and colon cancer cell lines. Expressed in several pancreatic tumors and weakly expressed in normal pancreatic tissue. Isoforms 1 and 5 are detected in several pancreatic cell lines.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Lymphoid enhancer-binding factor 1, LEF-1, T cell-specific transcription factor 1-alpha, TCF1-alpha, LEF1