Legumain Polyclonal Antibody | BS65876

Legumain Polyclonal Antibody | BS65876 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat,Dog,Cow,Horse,

Application: FCM,

Application Range: Flow-Cyt=1ug/test

Background: This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008].

Storage & Stability: Store at 4°C short term. Aliquot and store at -49°C long term. Avoid freeze-thaw cycles.

Specificity: Legumain Polyclonal Antibody detects endogenous levels of Legumain protein.

Molecular Weight: ~46kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: AEP; Asparaginyl endopeptidase; EC 3.4.22.34; LGMN; LGMN1; Protease, cysteine 1; protease, cysteine, 1 (legumain) ; PRSC1; LGMN_HUMAN.

Immunogen: KLH conjugated synthetic peptide derived from human Legumain:201-300/433

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: affinity purified by Protein A

Pathway: