Leptin, human recombinant | 4366

Leptin (Anti-Obesity Protein) is the protein product of the ob (obese) gene in mice and seems to be involved in appetite control. The ob gene is expressed in adipose tissue and is thought to regulate the body’s fat stores. Mice with the ob/ob genotype also develop a form of diabetes similar to type II (non-insulin dependent) diabetes. Human Leptin is a 16 kDa protein containing 146 amino acid residues.

4366 | Leptin human recombinant DataSheet

Biomolecule/Target: Leptin

Synonyms: OB Protein, Obesity Protein, OBS, Obesity factor.

Alternates names: Leukocyte interferon, B cell interferon, Type I interferon, IFNA2, IFN- 2a.

Taglines: Adipose-derived hormone which regulates energy intake & energy expenditure

NCBI Gene ID #: 3440

NCBI Gene Symbol: IFNA2

Gene Source: Human

Accession #: P01563

Recombinant: Yes

Source: Human 293 cell expressed

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: 98%

Assay #2: HPLC

Endotoxin Level: <0.1 ng/g

Activity (Specifications/test method): N/A

Biological activity: ED is typically 0.02 to 0.08 ng/mL. The specific activity was determined by the dose-dependent cytotoxicity of the human TF -1 cell line(human erythroleukemic indicator cell line).

Results: 0.02 to 0.08 ng/ml

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 16 kDa, monomer, glycosylated

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: Sterile filtered and lyophilized

Reconstitution Instructions: Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.

Amino acid sequence: N/A