Leptin Receptor, human recombinant | 4582

Leptin receptor (LEPR), also known as OB-R and B219, is a single transmembrane-domain receptor of the cytokine receptor family. Leptin receptor exists as homodimer and binds Leptin with high affinity, thus mediates the biological function of the adipocyte-specific hormone Leptin. LEPR is expressed at high levels in hematopoietic stem cells, lymphohematopoietic cell lines, as well as adult reproductive organs. Several isoforms of LEPR have been identified, and LEPR structurally contains two hemopoietin receptor domains, a fibronectin type III domain and a WSXWS domain within the extracellular region. Interaction of leptin and leptin receptor is crucial for bodyweight and bone mass regulation in mammals through hypothalamic effects on satiety and energy expenditure. Meanwhile, research data supports a leptin receptor activation model based on ligand-induced conformational changes.

4582 | Leptin Receptor human recombinant DataSheet

Biomolecule/Target: Leptin Receptor

Synonyms: OB Protein, Obesity Protein, OBS, Obesity factor

Alternates names: Leukocyte interferon, B cell interferon, Type I interferon, IFNA2, IFN- 2a.

Taglines: A receptor for the fat cell-specific hormone leptin

NCBI Gene ID #: 3440

NCBI Gene Symbol: IFNA2

Gene Source: Human

Accession #: P01563

Recombinant: Yes

Source: Human 293 cell expressed

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: HPLC

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: ED is typically 0.02 to 0.08 ng/mL. The specific activity was determined by the dose-dependent cytotoxicity of the human TF -1 cell line(human erythroleukemic indicator cell line).

Results: 0.02 to 0.08 ng/ml

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 16 kDa, monomer, glycosylated

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: Lyophilized from a 0.2 m filtered solution of PBS, pH7.4

Reconstitution Instructions: Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.

Amino acid sequence: N/A