Lestaurtinib | 1805

An indolocarbazole derivative with antineoplastic properties. Acts as a potent inhibitor of several tyrosine kinases including FLT3, JAK2, and TrkA with IC₅₀ values of 3, 1, and <25 nM, respectively. It suppresses JAK2/STAT5 signaling and is effective against myeloproliferative disorders in vivo.

Lestaurtinib is a an indolocarbazole derivative with antineoplastic properties. Acts as a potent inhibitor of several tyrosine kinases including FLT3, JAK2, and TrkA with IC₅₀ values of 3, 1, and <25 nM, respectively. It suppresses JAK2/STAT5 signaling and is effective against myeloproliferative disorders in vivo.

1805 | Lestaurtinib DataSheet

Alternate Name/Synonyms: CEP-701; KT-5555; SPM-924

Appearance: Colorless solid

Formulation: N/A

CAS Number: 111358-88-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₆H₂₁N₃O₄

Molecular Weight: 439.46

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (100 mg/ml) and Ethanol (20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A PTK inhibitor

MDL Number: MFCD12828858

PubChem CID: 126565

SMILES: CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(CO)O

InChi: InChI=1S/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12H2,1H3,(H,27,31)/t18-,25+,26+/m1/s1

InChi Key: UIARLYUEJFELEN-LROUJFHJSA-N