Letrozole | B2042

Letrozole is a third-generation nonsteroidal cell-permeable aromatase inhibitor (IC₅₀ = 2 nM). It is a competitive inhibitor of the aromatase enzyme system and thus inhibits the conversion of androgens to estrogens. Useful in the treatment of postmenopausal breast cancer.

Letrozole is a third-generation nonsteroidal cell-permeable aromatase inhibitor (IC₅₀ = 2 nM). It is a competitive inhibitor of the aromatase enzyme system and thus inhibits the conversion of androgens to estrogens. Useful in the treatment of postmenopausal breast cancer.

B2042 | Letrozole DataSheet

Alternate Name/Synonyms: 4,4′-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 112809-51-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₁₁N₅

Molecular Weight: 285.3

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>50 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A nonsteroidal aromatase inhibitor

MDL Number: MFCD00866241

PubChem CID: 3902

SMILES: C1=CC(=CC=C1C#N)C(C2=CC=C(C=C2)C#N)N3C=NC=N3

InChi: InChI=1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H

InChi Key: HPJKCIUCZWXJDR-UHFFFAOYSA-N